Assessment of abuse of tianeptine from a reimbursement database using 'doctor-shopping' as an indicator.

Frank Rouby, Vincent Pradel, Elisabeth Frauger, Vanessa Pauly, François Natali, Patrick Reggio, Xavier Thirion, Joëlle Micallef

CEIP-Addictovigilance PACA-Corse, Fédération de Pharmacologie et de Toxicologie, CHU Timone, Marseille, France.

Fundamental & clinical pharmacology 2012 Apr

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Doctor-shopping is a patient behaviour characterized by simultaneous consultations of several physicians during the same period. Some case reports have described an abuse of tianeptine, an atypical antidepressant. Our objective was to assess the extent of abuse of this drug with a method quantifying doctor-shopping in comparison with other antidepressants and benzodiazepines (BZD). All dispensations of antidepressants and BZD during the year 2005 in a French area of 4.5 million inhabitants were extracted from a reimbursement database. For each patient, two quantities were computed: quantity dispensed and obtained by doctor-shopping. Tianeptine and other drugs were compared using their doctor-shopping indicator (DSI), defined as the percentage of drug obtained by doctor-shopping among dispensed quantity; 410 525 patients received at least one antidepressant dispensation during the year 2005. Tianeptine was the sixth most dispensed antidepressant. The DSI of tianeptine was 2.0%, ranking it first among antidepressant (the second being mianserine with a DSI of 1%). Flunitrazepam has the highest DSI (30.2%), the DSI of the five following BZD (clonazepam, zolpidem, oxazepam, diazepam, bromazepam) range from 3.0% to 2.0%. Tianeptine is associated with higher DSI, compared with other antidepressants, suggesting that it may be subject to abuse in the population. Moreover, its DSI as a measure of diversion is similar to the DSI of diazepam or bromazepam. © 2011 The Authors Fundamental and Clinical Pharmacology © 2011 Société Française de Pharmacologie et de Thérapeutique.

Citation

Frank Rouby, Vincent Pradel, Elisabeth Frauger, Vanessa Pauly, François Natali, Patrick Reggio, Xavier Thirion, Joëlle Micallef. Assessment of abuse of tianeptine from a reimbursement database using 'doctor-shopping' as an indicator. Fundamental & clinical pharmacology. 2012 Apr;26(2):286-94