Synthesis and characterization of 5-hydroxymethyl-5-methyl-pyrroline N-oxide and its derivatives.

Klaus Stolze, Natascha Rohr-Udilova, Anjan Patel, Thomas Rosenau

Department of Biomedical Sciences, University of Veterinary Medicine Vienna, Austria. klaus.stolze@vetmeduni.ac.at

Bioorganic & medicinal chemistry 2011 Jan 15

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Synthesis and spin trapping behavior of three novel DMPO derivatives, namely 5-hydroxymethyl-5-methyl-pyrroline N-oxide (HMMPO), 5-(2-furanyl)-oxymethyl-5-methyl-pyrroline N-oxide (FMMPO), and 5-(2-pyranyl)-oxymethyl-5-methyl-pyrroline N-oxide (PMMPO) towards different oxygen- and carbon-centered radicals are described. The stabilizing effect of a series of cyclodextrins on the superoxide adducts was tested. Copyright Â© 2010 Elsevier Ltd. All rights reserved.

Citation

Klaus Stolze, Natascha Rohr-Udilova, Anjan Patel, Thomas Rosenau. Synthesis and characterization of 5-hydroxymethyl-5-methyl-pyrroline N-oxide and its derivatives. Bioorganic & medicinal chemistry. 2011 Jan 15;19(2):985-93