Synthesis and antiviral evaluation of bisnoradamantane sulfites and related compounds.

Elena Valverde, Eva Torres, Salvador Guardiola, Lieve Naesens, Santiago Vázquez

Laboratori de Química Farmacèutica (Unitat Associada al CSIC), Facultat de Farmàcia and Institute of Biomedicine, Universitat de Barcelona, Av. Diagonal, 643, 08028 Barcelona, Spain.

Medicinal chemistry (Shāriqah (United Arab Emirates)) 2011 Mar

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The reaction of a series of 1,2-diols with thionyl chloride led to bisnoradamantane sulfites in very good yields. The reaction has also been applied to related polycyclic scaffolds. The compounds have been tested for antiviral activity but none of them showed to be active. Several attempts to generate and trap SO from these polycyclic sulfites have been unsuccessful.

Citation

Elena Valverde, Eva Torres, Salvador Guardiola, Lieve Naesens, Santiago Vázquez. Synthesis and antiviral evaluation of bisnoradamantane sulfites and related compounds. Medicinal chemistry (Shāriqah (United Arab Emirates)). 2011 Mar;7(2):135-9