Prevention of clinical and histological signs of proteolipid protein (PLP)-induced experimental allergic encephalomyelitis (EAE) in mice by the water-soluble carbon monoxide-releasing molecule (CORM)-A1.

P Fagone, K Mangano, C Quattrocchi, R Motterlini, R Di Marco, G Magro, N Penacho, C C Romao, F Nicoletti

Department of Biomedical Sciences, School of Medicine, University of Catania, Italy.

Clinical and experimental immunology 2011 Mar

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We have evaluated the effects of the carbon monoxide-releasing molecule CORM-A1 [Na(2) (BH(3) CO(2) ); ALF421] on the development of relapsing-remitting experimental allergic encephalomyelitis (EAE) in SJL mice, an established model of multiple sclerosis (MS). The data show that the prolonged prophylactic administration of CORM-A1 improves the clinical and histopathological signs of EAE, as shown by a reduced cumulative score, shorter duration and a lower cumulative incidence of the disease as well as milder inflammatory infiltrations of the spinal cords. This study suggests that the use of CORM-A1 might represent a novel therapeutic strategy for the treatment of multiple sclerosis. © 2011 The Authors. Clinical and Experimental Immunology © 2011 British Society for Immunology.

Citation

P Fagone, K Mangano, C Quattrocchi, R Motterlini, R Di Marco, G Magro, N Penacho, C C Romao, F Nicoletti. Prevention of clinical and histological signs of proteolipid protein (PLP)-induced experimental allergic encephalomyelitis (EAE) in mice by the water-soluble carbon monoxide-releasing molecule (CORM)-A1. Clinical and experimental immunology. 2011 Mar;163(3):368-74