Molsidomine modulates the cNOS activity in an experimental model of cholinergic damage induced by 192-IgG saporin.

M Alejandra Hernández-Melesio, Dinora González-Esquivel, Alma Ortíz-Plata, Alicia Sánchez-Mendoza, Aurora Sánchez-García, Mireya Alcaraz-Zubeldia, Camilo Ríos, Francisca Pérez-Severiano

Departamento de Neuroquímica, Instituto Nacional de Neurología y Neurocirugía, "Manuel Velasco Suárez", Insurgentes Sur # 3877, Col. La Fama, C.P. 14269, Tlalpan, México D.F., Mexico.

Neuroscience letters 2011 Mar 17

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The aim of this work was to study the effect of molsidomine (MOLS), a nitric oxide (NO) donor, on the nitrergic system changes in an experimental model of cholinergic damage induced by 192 IgG saporin (SAP). Male rats were injured by intraseptal administration of SAP (0.22 μg), after seven days, rats were administered with MOLS (4 mg/kg, i.p.) 60 min before sacrifice. Prefrontal cortex (PC), striatum (S) and hippocampus (HC) were dissected out. Results showed significant recovery of the constitutive NOS activity (cNOS) in PC and S regions by MOLS but not in HC compared against controls. SAP reduced the cellular population in the lesion site and MOLS was able to avoid the progression of damage in this area. NO donor is able to modulate the nitrergic status in an experimental model induced by SAP. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

Citation

M Alejandra Hernández-Melesio, Dinora González-Esquivel, Alma Ortíz-Plata, Alicia Sánchez-Mendoza, Aurora Sánchez-García, Mireya Alcaraz-Zubeldia, Camilo Ríos, Francisca Pérez-Severiano. Molsidomine modulates the cNOS activity in an experimental model of cholinergic damage induced by 192-IgG saporin. Neuroscience letters. 2011 Mar 17;491(2):133-7