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This work develops an electrochemical approach for rapid detection of the genomic DNA methylation level, assay of methyltransferase activity, and evaluation and screening of the inhibitors of methyltransferase. This method may be a help for the discovery of anticancer drugs.


Shuna Liu, Ping Wu, Wen Li, Hui Zhang, Chenxin Cai. An electrochemical approach for detection of DNA methylation and assay of the methyltransferase activity. Chemical communications (Cambridge, England). 2011 Mar 14;47(10):2844-6

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PMID: 21253634

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