An electrochemical approach for detection of DNA methylation and assay of the methyltransferase activity.

Shuna Liu, Ping Wu, Wen Li, Hui Zhang, Chenxin Cai

Jiangsu Key Laboratory of Power Batteries, Laboratory of Electrochemistry, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210097, China.

Chemical communications (Cambridge, England) 2011 Mar 14

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This work develops an electrochemical approach for rapid detection of the genomic DNA methylation level, assay of methyltransferase activity, and evaluation and screening of the inhibitors of methyltransferase. This method may be a help for the discovery of anticancer drugs.

Citation

Shuna Liu, Ping Wu, Wen Li, Hui Zhang, Chenxin Cai. An electrochemical approach for detection of DNA methylation and assay of the methyltransferase activity. Chemical communications (Cambridge, England). 2011 Mar 14;47(10):2844-6