Correlation of the expressions of VEGF-C and VEGFR-3 to the pathological grade of prostate cancer].

To investigate the correlation of the expression of VEGF-C and VEGFR-3 to the pathological grade of human prostate cancer. Immunohistochemistry was used to detect the expression of VEGF-C and VEGFR-3 in 25 cases of prostate cancer tissues. The total positivity rates of VEGF-C and VEGFR-3 were 80% and 76% in these cancer tissues, respectively. The positivity rates of VEGF-C was 94.7% in the 19 cases with Gleason scores no less than 6 (group I), significantly higher than the rate (33%) in the 6 cases with Gleason scores between 4 and 6 (group II) (P<0.01). The positivity rates for VEGFR-3 also showed a significant difference between groups I and II (89.5% vs 33.3%, P<0.05). The expression level of VEGF-C was correlated to the Gleason score of prostate cancer (R=0.436, P<0.05), and the correlation between VEGFR-3 and the Gleason score was even more obvious (R=0.608, P<0.01). Their expressions, however, did not show any correlations to the patients age, PSA or the volume of the prostate. VEGF-C and VEGFR-3 may serve as new markers for evaluating the malignancy of prostate cancer with Gleason score not less than 4.

Citation

Hu Chen, Guo-ping Zhao, Ning-xin Xiao, Qiang Xia, Jian-sheng Lai, Dong-sheng Zheng, Zhen-hua Zhao, Yu-hong Xin. Correlation of the expressions of VEGF-C and VEGFR-3 to the pathological grade of prostate cancer]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2011 Jan;31(1):155-9

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PMID: 21269982

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