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To investigate the genes associated with temporal epilepsy and explore the molecular mechanism of epilepsy. The microarray data of temporal epilepsy were downloaded from the Gene Expression Omnibus (GEO) database and analyzed by bioinformatics methods using String, KEGG and Panther databases. Of all the 71 differentially expressed genes, 51 were found to encode proteins with interactions; the main biological pathways involved included neuroactive ligand-receptor interactions, MAPK signaling pathway, and calcium signaling pathway etc. The pathogenesis of epilepsy involves multiple genes, and investigations of these genes may provide valuable insights into the mechanism of epilepsy.


Ye Zhou, Rong Shi, Yong Bao, Chang-zheng Li, Wei Xie, Wen-ling Zheng, Wen-li Ma. Bioinformatic analysis of genes related to temporal epilepsy]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2011 Jan;31(1):180-3

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PMID: 21269987

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