Synthesis, biology and clinical significance of pentacyclic triterpenes: a multi-target approach to prevention and treatment of metabolic and vascular diseases.

Center for Drug Discovery, College of Pharmacy, China Pharmaceutical University, Nanjing, 210009, China. hbsun2000@yahoo.com

Natural product reports 2011 Mar

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This review (with 335 references cited) is devoted to pentacyclic triterpenes. The total synthesis, semi-synthesis, structural modification, and metabolic behavior of naturally occurring pentacyclic triterpenes are described. We also cover the in vivo evidence, mechanistic studies, and clinical significance of pentacyclic triterpenes as multi-target therapeutic agents for the prevention and treatment of metabolic and vascular diseases.

Citation

Huaming Sheng, Hongbin Sun. Synthesis, biology and clinical significance of pentacyclic triterpenes: a multi-target approach to prevention and treatment of metabolic and vascular diseases. Natural product reports. 2011 Mar;28(3):543-93