Commercial mouthwashes are more effective than azole antifungals against Candida albicans biofilms in vitro.

Gordon Ramage, Anto Jose, Brent Coco, Ranjith Rajendran, Riina Rautemaa, Colin Murray, David F Lappin, Jeremy Bagg

Glasgow Dental School, School of Medicine, College of Medicine, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom. gordon.ramage@glasgow.ac.uk

Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 2011 Apr

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The aim of this study was to evaluate and compare the activity of prescription and over-the-counter antimicrobial compounds against planktonic and biofilm forms of Candida albicans isolated from cases of oral candidiasis in vitro. The efficacy of azoles, polyenes, an echinocandin, and 4 over-the-counter mouthwashes were tested against C. albicans-derived planktonic and biofilm cells. Planktonic cells were shown to be highly sensitive to all of the antifungal agents tested. Sessile cells were highly resistant to azoles (≥128 mg/L) but equally sensitive to caspofungin and short treatments with Corsodyl, Listerine, and Oraldene. Although C. albicans is sensitive to azole antifungal agents in planktonic form, it is highly resistant within the biofilm. The good efficacy of the over-the-counter mouthwashes against candidal biofilms in vitro suggests that clinical trials should now be designed to establish their role in the clinical management of oral candidal infections. Copyright © 2011 Mosby, Inc. All rights reserved.

Citation

Gordon Ramage, Anto Jose, Brent Coco, Ranjith Rajendran, Riina Rautemaa, Colin Murray, David F Lappin, Jeremy Bagg. Commercial mouthwashes are more effective than azole antifungals against Candida albicans biofilms in vitro. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics. 2011 Apr;111(4):456-60