Actions of a coral toxin analogue (bipinnatin-B) on an insect nicotinic acetylcholine receptor.

D Bai, S N Abramson, D B Sattelle

AFRC Luboratory of Molecular Signalling, Department of Zoology, University of Cambridge,Cambridge, United Kingdom.

Archives of insect biochemistry and physiology 1993

filter terms:

The lophotoxin analogue, bipinnatin-B, is a potent neurotoxin isolated from the gorgonian coral Pseudopterogorgia bipinnata. When tested on the cell body of an identified motor neurone, the fast coxal depressor motor neurone (Df) in the cockroach metathoracic ganglion, bipinnatin-B, at concentrations of 10 micronM,partially blocked nicotine-induced depolarization. Blockade of the response to nicotine was almost complete at 30 micronM bipinnatin-B, and was partially reversible on rebathing the preparation in normal saline. Responses of the same neurone to GABA were unaffected by 30 micronM bipinnatin-B.

Citation

D Bai, S N Abramson, D B Sattelle. Actions of a coral toxin analogue (bipinnatin-B) on an insect nicotinic acetylcholine receptor. Archives of insect biochemistry and physiology. 1993;23(4):155-9