Automated preparation of Re-188 lipiodol for the treatment of hepatocellular carcinoma.

Licia Uccelli, Micol Pasquali, Alessandra Boschi, Melchiore Giganti, Adriano Duatti

Laboratory of Nuclear Medicine, Department of Radiological Sciences, University of Ferrara, 44121 Ferrara, Italy.

Nuclear medicine and biology 2011 Feb

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The iodinated oil lipiodol is commonly used as a carrier for in situ delivery of drugs or radioactivity to hepatic tumors. Recently, we reported a new kit formulation for high-activity labeling of lipiodol with the β-emitting radionuclide Re-188. Since the whole preparation involves different steps and complex manipulations of high-activity samples, we describe here an automated synthesis module that allows the easy preparation of sterile and pyrogen-free samples of Re-188 lipiodol ready to be administered to the patient. Important advantages include the possibility to incorporate high Re-188 activity into the lipiodol hydrophobic phase and a sharp reduction of radiation exposure of the operator assisting the labelling procedure. Application of this modular reaction system could be also extended to the preparation of other Re-188 radiopharmaceuticals and to compound labelled with different β-emitting therapeutic radionuclides. Copyright © 2011 Elsevier Inc. All rights reserved.

Citation

Licia Uccelli, Micol Pasquali, Alessandra Boschi, Melchiore Giganti, Adriano Duatti. Automated preparation of Re-188 lipiodol for the treatment of hepatocellular carcinoma. Nuclear medicine and biology. 2011 Feb;38(2):207-13