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The first total synthesis of 6(E),8(Z),11(Z),13(E) 5-oxo-15-HETE 4 was accomplished. The synthetic material was evaluated with calcium mobilization assay and compared with 5-oxo-ETE the natural ligand for the OXE receptor. Copyright © 2011 Elsevier Ltd. All rights reserved.

Citation

Pranav Patel, Jaganmohan R Anumolu, William S Powell, Joshua Rokach. 5-oxo-15-HETE: total synthesis and bioactivity. Bioorganic & medicinal chemistry letters. 2011 Mar 15;21(6):1857-60

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PMID: 21316960

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