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We report a case of colonic malacoplakia in a 78-year-old woman, developed following short-term treatment with prednisolone. Clinically, the patient presented with diarrhoea (up to ten times a day) and malaise. Laboratory tests revealed severe anaemia and elevated inflammatory parameters. Colonoscopy showed macroscopic yellowish nodular changes throughout the colon. Biopsies were diagnostic for malacoplakia and exhibited moderate growth of Escherichia faecium and ciprofloxacin-resistant Escherichia coli. The condition resolved during three months of antibiotic treatment with sulfamethizole and trimethoprim.


Mikkel Christensen, Svend Knuhtsen, Elisabeth Knudsen. Colonic malacoplakia treated with sulfamethizole and trimethoprim]. Ugeskrift for laeger. 2011 Feb 14;173(7):509-10

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PMID: 21320418

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