Ethosuximide and phenobarbital promote wound healing via enhancing collagenization.

Dema M Ajwee, Ahmad M Disi, Eyad A Qunaibi, Mutasem O Taha

Department of Biological Sciences, Faculty of Sciences, University of Jordan, Amman, Jordan.

Chemical biology & drug design 2012 Jan

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The fact that ethosuximide (ETO), phenobarbital (PHO), and barbituric acid (BARB) share structural and pharmacophoric homologies with phenytoin and allantoin, both known to have significant wound-healing properties, prompted us to evaluate them as wound-healing agents. Accordingly, ETO-, PHO-, and BARB-containing ointments were applied onto full-thickness excision and incision wounds created on the dorso-lumbar region of experimental rats. ETO-and PHO-treated incision wounds illustrated significant enhancement in breaking strengths (1380 ± 61 and 1240 ± 42 g, respectively) compared to vehicle controls (1070 ± 18 g) and BARB (1080 ± 45 g). Moreover, biochemical analyses revealed significant increase in hydroxyproline contents in ETO- and PHO-treated wounds compared to vehicle controls. Histological evaluation revealed that both ETO and PHO promoted collagen synthesis and deposition. This is the first time to describe the significant wound-healing merits of ETO and PHO as potential clinical agents for treatment of chronic wounds. © 2011 John Wiley & Sons A/S.

Citation

Dema M Ajwee, Ahmad M Disi, Eyad A Qunaibi, Mutasem O Taha. Ethosuximide and phenobarbital promote wound healing via enhancing collagenization. Chemical biology & drug design. 2012 Jan;79(1):137-42