Regulation of lipid homeostasis by the bifunctional SREBF2-miR33a locus.

Laboratory of Physiological Chemistry, de Duve Institute, Université Catholique de Louvain, Avenue Hippocrate 75.39, 1200 Bruxelles, Belgium. guido.bommer@uclouvain.be

Cell metabolism 2011 Mar 2

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The sterol regulatory element-binding factor-2 (SREBF2) gene is a bifunctional locus encoding SREBP-2, a well-known transcriptional regulator of genes involved in cholesterol biosynthesis, and microRNA-33a, which has recently been shown to reduce expression of proteins involved in export of cholesterol and β-oxidation of fatty acids, thus adding an unexpected layer of complexity and fine-tuning to regulation of lipid homeostasis. Copyright © 2011 Elsevier Inc. All rights reserved.

Citation

Guido T Bommer, Ormond A MacDougald. Regulation of lipid homeostasis by the bifunctional SREBF2-miR33a locus. Cell metabolism. 2011 Mar 2;13(3):241-7