The effect of female hormones upon urate transport systems in the mouse kidney.

Yuichi Takiue, Makoto Hosoyamada, Masaki Kimura, Hidetsugu Saito

Division of Pharmacotherapeutics, Keio University Faculty of Pharmacy, Tokyo, Japan.

Nucleosides, nucleotides & nucleic acids 2011 Feb

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Increased levels of serum urat e in postmenopausal women are thought to be caused by a change in renal urate elimination associated with the loss of female hormones. In this study, we investigated the regulation of renal urate transporter expression by female hormones using ovariectomized mice with or without hormone replacement. Estradiol suppressed the protein levels of urate reabsorptive transporters urate transporter 1 and glucose transporter 9 (Urat1 and Glut9), and that of urate efflux transporter ATP-binding cassette sub-family G member 2 (Abcg2). Progesterone suppressed protein levels of sodium-coupled monocarboxylate transporter 1 (Smct1). However, neither estradiol nor progesterone influenced the respective levels of mRNA.

Citation

Yuichi Takiue, Makoto Hosoyamada, Masaki Kimura, Hidetsugu Saito. The effect of female hormones upon urate transport systems in the mouse kidney. Nucleosides, nucleotides & nucleic acids. 2011 Feb;30(2):113-9