Protuboxepins A and B and protubonines A and B from the marine-derived fungus Aspergillus sp. SF-5044.

Sang Un Lee, Yukihiro Asami, Dongho Lee, Jae-Hyuk Jang, Jong Seog Ahn, Hyuncheol Oh

College of Medical and Life Sciences, Silla University, Busan 617-736, Republic of Korea.

Journal of natural products 2011 May 27

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Two new oxepin-containing (1 and 2) and two diketopiperazine-type alkaloids (3 and 4) have been isolated from an EtOAc extract of the marine-derived fungus Aspergillus sp. SF-5044. The structures of these metabolites were determined through analysis of NMR and MS data, along with Marfey's method. Compound 1 showed weak growth inhibitory activity against a small panel of cell lines.

Citation

Sang Un Lee, Yukihiro Asami, Dongho Lee, Jae-Hyuk Jang, Jong Seog Ahn, Hyuncheol Oh. Protuboxepins A and B and protubonines A and B from the marine-derived fungus Aspergillus sp. SF-5044. Journal of natural products. 2011 May 27;74(5):1284-7