Fluorescence turn on by cholate aggregates.

Anthony Baldridge, Adrian Amador, Laren M Tolbert

School of Chemistry and Biochemistry, 901 Atlantic Drive, Georgia Institute of Technology, Atlanta, Georgia 30332-0400, United States.

Langmuir : the ACS journal of surfaces and colloids 2011 Apr 5

filter terms:

Bile salts, including sodium cholate (NaCh), are amphiphilic molecules with a concave hydrophilic side and a convex hydrophobic side. By forming aggregates in aqueous solution, these natural surfactants fulfill vital biological roles in the solubilization of cholesterol, lipids, and fat-soluble vitamins and thus are involved in the transport and absorption of important biological molecules. Following our success with the encapsulation of fluorescent protein chromophore (FP) analogs by synthetic hydrophobic and hydrophilic hosts, based upon substitution patterns, we now report the binding and turn on of other analogs by bile salt aggregates, observations which may lead to new tools for studying trafficking in these important systems.

Citation

Anthony Baldridge, Adrian Amador, Laren M Tolbert. Fluorescence turn on by cholate aggregates. Langmuir : the ACS journal of surfaces and colloids. 2011 Apr 5;27(7):3271-4