Activity of garenoxacin against 536 unusual anaerobes including 128 recovered from acute pelvic infections.

Garenoxacin, a des-(F)6-quinolone, was tested using the agar dilution method against 536 anaerobic bacteria, composed of 408 unusual strains from various sources and 128 pelvic isolates. Only 33/408 (8%) unusual isolates and 6/128 (4.7%) pelvic isolates had garenoxacin MICs ≥ 4 μg/mL, and 18 and 3 (4.4% and 2.3% of the respective totals) had MICs ≥ 8 μg/mL. Less susceptible unusual isolates included 7/15 Veillonella sp. from various clinical sources, 6/14 Fusobacterium varium from predominantly abdominal infections, 5/5 F. russii (cat bites), and 6/9 Actinomyces israelii. Overall, garenoxacin showed good activity against the isolates studied and has potential utility in mixed aerobic/anaerobic infections. Copyright © 2011 Elsevier Inc. All rights reserved.

Citation

Ellie J C Goldstein, Diane M Citron, Kerin L Tyrrell, C Vreni Merriam. Activity of garenoxacin against 536 unusual anaerobes including 128 recovered from acute pelvic infections. Diagnostic microbiology and infectious disease. 2011 May;70(1):131-6

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PMID: 21398076

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