ERRs and cancers: effects on metabolism and on proliferation and migration capacities.

Stéphanie Bianco, Juliette Sailland, Jean-Marc Vanacker

Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, Université Lyon 1, CNRS, Ecole Normale Supérieure de Lyon, 46 allée d'Italie, 69364 Lyon cedex 07, France.

The Journal of steroid biochemistry and molecular biology 2012 Jul

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ERRs are orphan members of the nuclear receptor superfamily which, at least for ERRα and ERRγ display important roles in the control of various metabolic processes. On other hand, correlations have been found between the expression of ERRα and γ and diverse parameters of tumor progression in human cancers. Whereas it is tempting to speculate that ERR receptors act in tumors through the regulation of metabolism, recent data have suggested that they also may directly regulate tumor proliferation and progression independently of their effects on metabolism. The two aspects of tumoral functions of ERR receptors are the purpose of the present review. Copyright © 2011 Elsevier Ltd. All rights reserved.

Citation

Stéphanie Bianco, Juliette Sailland, Jean-Marc Vanacker. ERRs and cancers: effects on metabolism and on proliferation and migration capacities. The Journal of steroid biochemistry and molecular biology. 2012 Jul;130(3-5):180-5