Antiproliferative activity and cell cycle analysis of 2-(3,5-dihydroxyphenyl)-6-hydroxybenzothiazole on MCF-7 breast and HCT-15 colon cancer cell lines.

Mehdi Rajabi, Filippo Minutolo, Simone Bertini, Marco Macchia, Riccardo Ghidoni

Department of Chemistry, Islamic Azad University, Neyshabur Branch, Neyshabur, Iran. m.rajabi.s@gmail.com

DNA and cell biology 2011 Aug

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The antiproliferative activity of 2-(3,5-Dihydroxyphenyl)-6-hydroxybenzothiazole (DHB) is reported here. DHB inhibits the growth of human colon cancer HCT-15 with a 50% cell growth inhibition value of 23 μM and breast cancer MCF-7 with a 50% cell growth inhibition value of 41 μM in a dose/time dependent manner by using sulforhodamine B assay. Cell cycle analysis by flow cytometry showed that DHB-induced growth arrest could be associated with apoptosis in both cell lines. Moreover, suppression of clonogenic activity occurs after exposure to DHB at a concentration of 25 μM for HCT-15 and of 40 μM for MCF-7.

Citation

Mehdi Rajabi, Filippo Minutolo, Simone Bertini, Marco Macchia, Riccardo Ghidoni. Antiproliferative activity and cell cycle analysis of 2-(3,5-dihydroxyphenyl)-6-hydroxybenzothiazole on MCF-7 breast and HCT-15 colon cancer cell lines. DNA and cell biology. 2011 Aug;30(8):617-21