Cocaine increases ryanodine receptors via dopamine D1 receptors.

Kazuhiro Kurokawa, Koji Mizuno, Masahiro Shibasaki, Emi Kiyokage, Kazunori Toida, Seito Ohkuma

Departments of Pharmacology, Kawasaki Medical School, Matsushima 577, Kurashiki 701-0192, Japan.

Synapse (New York, N.Y.) 2011 Oct

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For review there are little available data on regulatory mechanisms of ryanodine receptor (RyR) expression with cocaine treatment, though methamphetamine was reported to up-regulate RyRs in mouse brain. This study attempted to investigate regulatory mechanisms of RyR expression using the cerebral cortical neurons in primary culture intermittently exposed to a psychostimulant, cocaine. Intermittent exposure to cocaine (10 μM) significantly enhanced RyR 1 and 2 proteins and their mRNA, but not RyR 3 expression in the neurons. These cocaine-induced increases of RyR proteins and their mRNA were dose-dependently blocked by a dopamine D1 receptor antagonist (SCH23390), but not by a dopamine D2 receptor antagonist (sulpiride). These results indicate a regulatory role of dopamine D1 receptors in RyR expression bycocaine. Copyright © 2011 Wiley-Liss, Inc.

Citation

Kazuhiro Kurokawa, Koji Mizuno, Masahiro Shibasaki, Emi Kiyokage, Kazunori Toida, Seito Ohkuma. Cocaine increases ryanodine receptors via dopamine D1 receptors. Synapse (New York, N.Y.). 2011 Oct;65(10):1106-12