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It has been reported that the resistance index (RI) and pulsatility index (PI) are of limited value in differentiating lung cancers from benign lesions. We hypothesized that a vascular work index (VWI), derived from Doppler spectral waveforms, would yield better results. Forty-one patients were enrolled, 20 of them having malignancies and 21 having benign lesions. The VWI was defined as the square of peak systolic velocity times the time-velocity integral. Maximal VWI, minimal RI, and minimal PI of each tumor were used for analysis. Significantly higher VWI values were found in malignant tumors compared with benign lesions (p < 0.0001). VWI was shown by analysis of the receiver operating characteristic curve to be a best predictor of lung malignancies than PI and RI (p < 0.05), with a 0.89 (95% confidence interval, 0.80-0.98) area under the receiver operating characteristic curve. VWI may be a useful index to help differentiate malignant from benign lung tumors. Copyright © 2011 Wiley Periodicals, Inc.


Tsung-Ju Wu, Judith Shu-Chu Shiao, Jau-Yeong Lu. A novel Doppler spectral index for differentiating benign from malignant lung tumors. Journal of clinical ultrasound : JCU. 2011 Jun;39(5):256-62

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PMID: 21448999

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