A possible prevention strategy of radiation pneumonitis: combine radiotherapy with aerosol inhalation of hydrogen-rich solution.

Yunhai Chuai, Luqian Zhao, Jin Ni, Ding Sun, Jianguo Cui, Bailong Li, Liren Qian, Fu Gao, Jianming Cai

Department of Radiation Medicine, Faculty of Naval Medicine, 2nd Military Medical University, Shanghai, PR China.

Medical science monitor : international medical journal of experimental and clinical research 2011 Apr

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Radiotherapy is an important modality of cancer treatment. Radiation pneumonitis is a major obstacle to increasing the radiation dose in radiotherapy, and it is important to prevent this radiation-induced complication. Recent studies show that hydrogen has a potential as an effective and safe radioprotective agent by selectively reducing hydroxyl and peroxynitrite radicals. Since most of the ionizing radiation-induced cellular damage is caused by hydroxyl radicals, we hypothesize that a treatment combining radiotherapy with aerosol inhalation of a hydrogen-rich solution may be an effective and novel prevention strategy for radiation pneumonitis (hydrogen is explosive, while a hydrogen-rich solution such as physiological saline saturated with molecular hydrogen is safer).

Citation

Yunhai Chuai, Luqian Zhao, Jin Ni, Ding Sun, Jianguo Cui, Bailong Li, Liren Qian, Fu Gao, Jianming Cai. A possible prevention strategy of radiation pneumonitis: combine radiotherapy with aerosol inhalation of hydrogen-rich solution. Medical science monitor : international medical journal of experimental and clinical research. 2011 Apr;17(4):HY1-4