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The mechanisms that move chromatids poleward during anaphase A have fascinated researchers for decades. There is now growing evidence that this movement is tightly linked to the active depolymerization of both ends of kinetochore-associated microtubules, a mechanism we refer to as "Pacman-Flux." Contemporary data suggest that this is catalyzed by the integration of multiple enzymatic activities including (1) microtubule-end depolymerases housed at the pole or kinetochore, (2) microtubule-severing enzymes used to uncap the ends of kinetochore-associated microtubules, and (3) molecular motors which drive tubulins towards the pole or into kinetochores.


Uttama Rath, David J Sharp. The molecular basis of anaphase A in animal cells. Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology. 2011 Apr;19(3):423-32

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PMID: 21461696

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