A single-molecule study of the inhibition effect of Naringenin on transforming growth factor-β ligand-receptor binding.

Yong Yang, Yongchun Xu, Tie Xia, Fangjin Chen, Chunling Zhang, Wei Liang, Luhua Lai, Xiaohong Fang

Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Key Laboratory of Molecular Nanostructures and Nanotechnology, Chinese Academy of Sciences, Beijing 100190, PR China.

Chemical communications (Cambridge, England) 2011 May 21

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With single-molecule fluorescence imaging and single-molecule force measurement, we have found that the natural compound Naringenin exerts an inhibition effect on TGF-β ligand-receptor interaction, the initial step of TGF-β signaling. © The Royal Society of Chemistry 2011

Citation

Yong Yang, Yongchun Xu, Tie Xia, Fangjin Chen, Chunling Zhang, Wei Liang, Luhua Lai, Xiaohong Fang. A single-molecule study of the inhibition effect of Naringenin on transforming growth factor-β ligand-receptor binding. Chemical communications (Cambridge, England). 2011 May 21;47(19):5440-2