Biological and chemical characterization of metabolites of Fusarium moniliforme isolates.

N Hassanin, M A Gabal

Department of Nutrition and Food Chemistry, Ain-Shams University, Arab Republic of Egypt.

Veterinary and human toxicology 1990 Dec

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Metabolites of fusarium moniliforme isolates from different types of corn were characterized biologically and chemically. The biological assays included rat feeding, rat dermal tests and inoculation of embryonated eggs. Thin-layer chromatography, gas liquid chromatography, and mass spectrophotometry were used to isolate and determine their chemical identities. The metabolites were identified as diacetoxyscripenol, ipomeanol, ipomeanine and diplodiatoxin. The biological tests revealed significant weight loss in rats fed the contaminated corn for 5 w. Hemorrhages and edema in the brain and intestine were detected in all the groups of rats.

Citation

N Hassanin, M A Gabal. Biological and chemical characterization of metabolites of Fusarium moniliforme isolates. Veterinary and human toxicology. 1990 Dec;32(6):536-40