Inhibition of ganglioside biosynthesis as a novel therapeutic approach in insulin resistance.

Jin-Ichi Inokuchi

Division of Glycopathology and CREST, Japan. jin@tohoku-pharm.ac.jp

Handbook of experimental pharmacology 2011

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A new concept "Life style-related diseases, such as type 2 diabetes, are a membrane microdomain disorder caused by aberrant expression of gangliosides" has arisen. By examining this working hypothesis, we demonstrate the molecular pathogenesis of type 2 diabetes and insulin resistance focusing on the interaction between insulin receptor and gangliosides in microdomains microdomains and propose the new therapeutic strategy "membrane microdomain ortho-signaling therapy".

Citation

Jin-Ichi Inokuchi. Inhibition of ganglioside biosynthesis as a novel therapeutic approach in insulin resistance. Handbook of experimental pharmacology. 2011(203):165-78