Backscattering interferometry: an alternative approach for the study of hydrogen bonding interactions in organic solvents.

Esther N Pesciotta, Darryl J Bornhop, Robert A Flowers

Department of Chemistry, Lehigh University, Bethlehem, Pennsylvania 18015, United States.

Organic letters 2011 May 20

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catalysis (1)

hydrogen bonding (3)

interferometry (3)

microfluidic (2)

molecular structure (1)

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Intermolecular interactions involving hydrogen bonds are responsible for catalysis and recognition. Traditional methods used to study hydrogen-bonding interactions are generally limited to relatively large volumes and high substrate concentrations. Backscattering Interferometry (BSI) provides a microfluidic platform to study these interactions in nonaqueous media at micromolar to nanomolar concentrations in picoliter volumes by monitoring changes in the refractive index.

Citation

Esther N Pesciotta, Darryl J Bornhop, Robert A Flowers. Backscattering interferometry: an alternative approach for the study of hydrogen bonding interactions in organic solvents. Organic letters. 2011 May 20;13(10):2654-7