A highly stereoselective synthesis of a model C(18)-C(35) spiroketal unit (7) of integramycin has been accomplished via an enantioselective stannyl-crotylboration reaction and an N-iodosuccinimide-mediated spiroketalization of 19a.
Huikai Sun, Jason R Abbott, William R Roush. Stereoselective synthesis of a model C(18)-C(35) spiroketal fragment of integramycin. Organic letters. 2011 May 20;13(10):2734-7
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PMID: 21510632
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