Affinity to the nicotinic acetylcholine receptor and insecticidal activity of chiral imidacloprid derivatives with a methylated imidazolidine ring.

Hisashi Nishiwaki, Hikaru Nagaoka, Mituhiro Kuriyama, Satoshi Yamauchi, Yoshihiro Shuto

Faculty of Agriculture, Ehime University, Ehime, Japan.

Bioscience, biotechnology, and biochemistry 2011

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Four imidacloprid derivatives with an asymmetrically methylated imidazolidine ring were synthesized. Their affinity to the nicotinic acetylcholine receptor of housefly Musca domestica and insecticidal activity against the housefly were measured. The compound with a 5R-methylated imidazolidine ring demonstrated intrinsic activity comparable to that of the unsubstituted compound. Most of the compounds were synergized by oxygenase inhibitors.

Citation

Hisashi Nishiwaki, Hikaru Nagaoka, Mituhiro Kuriyama, Satoshi Yamauchi, Yoshihiro Shuto. Affinity to the nicotinic acetylcholine receptor and insecticidal activity of chiral imidacloprid derivatives with a methylated imidazolidine ring. Bioscience, biotechnology, and biochemistry. 2011;75(4):780-2