Amelioration of systemic lupus erythematosus by Withangulatin A in MRL/lpr mice.

Lijuan Sun, Lin Zhou, Mingcang Chen, Renqian Zhong, Jianwen Liu

Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.

Journal of cellular biochemistry 2011 Sep

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We have previously reported the anti-inflammatory potential and the possible underlying mechanisms of Withangulatin A (WA), which is an active component isolated from Physalis angulata L. Here, we demonstrated that WA might improve the life quality, as well as reduced the accumulation of proteinuria symptoms and levels of anti-double-stranded DNA antibodies in MRL/lpr mice. Moreover, WA could improve renal histopathologic characteristics of MRL/lpr mice. Intriguingly, expression of B cell-activating factor (BAFF), BAFF-R and related gene in the spleen were significantly reduced in 10 mg/kg WA-treated mice compared with that in 5 mg/kg WA-treated mice and untreated mice. These findings indicate that WA might have a pleiotropic therapeutic effect through their immunosuppression via inhibiting BAFF signaling, which suggest a potential application of this active constituent in the treatment of SLE. Copyright © 2011 Wiley-Liss, Inc.

Citation

Lijuan Sun, Lin Zhou, Mingcang Chen, Renqian Zhong, Jianwen Liu. Amelioration of systemic lupus erythematosus by Withangulatin A in MRL/lpr mice. Journal of cellular biochemistry. 2011 Sep;112(9):2376-82