Oxidative stress in sickle cell disease; pathophysiology and potential implications for disease management.

Erfan Nur, Bart J Biemond, Hans-Martin Otten, Dees P Brandjes, John-John B Schnog, CURAMA Study Group

Department of Internal Medicine, Slotervaart Hospital Amsterdam, The Netherlands. e.nur@amc.uva.nl

American journal of hematology 2011 Jun

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Sickle cell disease (SCD) is a hemoglobinopathy characterized by hemolytic anemia, increased susceptibility to infections and vaso-occlusion leading to a reduced quality of life and life expectancy. Oxidative stress is an important feature of SCD and plays a significant role in the pathophysiology of hemolysis, vaso-occlusion and ensuing organ damage in sickle cell patients. Reactive oxygen species (ROS) and the (end-)products of their oxidative reactions are potential markers of disease severity and could be targets for antioxidant therapies. This review will summarize the role of ROS in SCD and their potential implication for SCD management. Copyright © 2011 Wiley-Liss, Inc.

Citation

Erfan Nur, Bart J Biemond, Hans-Martin Otten, Dees P Brandjes, John-John B Schnog, CURAMA Study Group. Oxidative stress in sickle cell disease; pathophysiology and potential implications for disease management. American journal of hematology. 2011 Jun;86(6):484-9