Hypersensitivity to repaglinide.

P Rojas, L Sánchez, A Santos, M P Góõmez, H Blanco, J J Laguna

Allergy Unit, Hospital Central de la Cruz Roja, Madrid, Spain. projasperezezquera@seaic.org

Journal of investigational allergology & clinical immunology 2011

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Meglitinides (repaglinide and nateglinide) are insulin secretagogues used to treat diabetes mellitus. We present a case of hypersensitivity reaction to repaglinide in a 61-year-old man who developed a maculopapular rash 5 days after treatment. Skin prick tests including repaglinide (0.5 g/mL) and patch tests (0.05% in pet and saline) were performed, and the results were negative. A blind oral challenge test with repaglinide was performed and the therapeutic dose was subsequently taken at home every 24 hours for 7 days. The result was positive with a delayed reaction at day 3. A punch biopsy of the skin lesions revealed drug-induced exanthema. The clinical manifestations, the latency period, the reappearance of cutaneous lesions after rechallenge, and the histopathology report of the skin biopsy suggest a type IV mechanism.

Citation

P Rojas, L Sánchez, A Santos, M P Góõmez, H Blanco, J J Laguna. Hypersensitivity to repaglinide. Journal of investigational allergology & clinical immunology. 2011;21(3):245-7