Optimization of the radiosynthesis of the Alzheimer tracer 2-(4-N-[11C]methylaminophenyl)-6-hydroxybenzothiazole ([11C]PIB).

C Philippe, D Haeusler, M Mitterhauser, J Ungersboeck, H Viernstein, R Dudczak, W Wadsak

Department of Nuclear Medicine, Medical University of Vienna, Radiochemistry and Biomarker Development Unit, Austria.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 2011 Sep

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11)C]PIB is still the standard PET compound for Alzheimer imaging targeting beta-amyloid plaques. We aimed to establish a fully-automated procedure for the synthesis and purification of [(11)C]PIB with a high degree of reliability and improved specific activity as well as a suitable and fast quality control assay. The optimum reaction conditions were 75°C, 4 mg/mL precursor yielding at 48.0±2.7% (EOS, based on [(11)C]CH(3)OTf, corrected for decay), 183±14 GBq/μmol specific activity and >99% radiochemical purity. Time consumption was kept to a minimum (40 min from EOB) and overall yields were enough to serve 2 consecutive patients with a single preparation. Copyright © 2011 Elsevier Ltd. All rights reserved.

Citation

C Philippe, D Haeusler, M Mitterhauser, J Ungersboeck, H Viernstein, R Dudczak, W Wadsak. Optimization of the radiosynthesis of the Alzheimer tracer 2-(4-N-[11C]methylaminophenyl)-6-hydroxybenzothiazole ([11C]PIB). Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. 2011 Sep;69(9):1212-7