NMR characterization of a Cu(I)-bound peptide model of copper metallochaperones: insights on the role of methionine.

Michal S Shoshan, Deborah E Shalev, Wencke Adriaens, Maarten Merkx, Tilman M Hackeng, Edit Y Tshuva

Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem, Israel.

Chemical communications (Cambridge, England) 2011 Jun 14

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The first NMR structure of a Cu(I)-bound metallochaperone model with the conserved sequence MT/HCXXC revealed that at pH ∼3.0 and ∼6.8 Cu(I) binds through one Cys and the Met rather than the two Cys residues, differently than at pH ∼8.5. This suggests a possible role of Met in metal transport. This journal is © The Royal Society of Chemistry 2011

Citation

Michal S Shoshan, Deborah E Shalev, Wencke Adriaens, Maarten Merkx, Tilman M Hackeng, Edit Y Tshuva. NMR characterization of a Cu(I)-bound peptide model of copper metallochaperones: insights on the role of methionine. Chemical communications (Cambridge, England). 2011 Jun 14;47(22):6407-9