Effect of tetramethylpyrazine on JAK-STAT signal transduction in cardiomyocyte hypertrophy].

Mei-hua Gao, Li Zhang, Bing Li, Shu-rong Ren, Bei Zhang

Department of Immunology, Medical College, Qingdao University, Qingdao 266000, China. meihuagao@yahoo.com.cn

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 2011 May

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To study the effect of Tetramethylpyrazine (TMZ), the extracts of Chinese Herbs which accelerat blood circulation, on JAK-STAT signal transduction in cardiomyocyte hypertrophy. Cardiomyocyte hypertrophy Wistar rats model was established. The cardiomyocytes were seperated from one-day-old neonatal rats. The total RNA of cardiomyocytes was extracted by TRIzol reagent. Then the ANP mRNA were detected by RT-PCR. pJAK2, pJAK1 and pSTAT3 molecules were analysed by Western blot respectively. Statistics analysis showed that TMZ significantly decreased the expression of ANP mRNA in cardiomyocytes (P<0.01), and that TMZ also decreased the levels of pJAK2, pJAK1 or pSTAT3 (P<0.01). TMZ has the inhibitory effect on JAK-STAT signal transduction in cardiomyocyte hyertrophy, suggesting the clinical application of traditional Chinese medicine on cardiomyocyte hypertrophy treatment.

Citation

Mei-hua Gao, Li Zhang, Bing Li, Shu-rong Ren, Bei Zhang. Effect of tetramethylpyrazine on JAK-STAT signal transduction in cardiomyocyte hypertrophy]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. 2011 May;27(5):519-21, 524