Tristan Gauthier, Sophie Mazeau, François Dalmay, Jean-Luc Eyraud, Cyril Catalan, Benoit Marin, Yves Aubard
Department of Gynaecology and obstetrics, Hospital Mère Enfant, CHU Dupuytren, av Larrey 87000 Limoges, France. gauthiertristan@yahoo.fr
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2012 MarTo estimate the impact of obesity on cervical ripening with prostaglandin E2 (PGE2). A retrospective study compared the cervical ripening efficiency of PGE2 on patients with BMI above 30 kg/m(2) and normal weight patients with BMI between 20 kg/m(2) and 25 kg/m(2). In case of a Bishop score (≤3), a dinoprostone tampon was used over 12 h. In case of a Bishop score (4;6), a dinoprostone gel was used over 6 h. Failure of first cervical ripening attempt was defined, as the persistence of a Bishop score <6, 12 h after dinoprostone tampon or 6 h after dinoprostone gel. Ninety-five obese patients were matched according to parity to 190 non-obese patients. The failure rate of the first attempt at cervical ripening was significantly higher (P = 0.0016) among obese patients (53.7%) as compared to patients with a BMI in between 20 and 25 (34.2%). After multivariate analysis BMI ≥ 30 (OR = 2.32 (1.47-4.00), P = 0.0019), parity ≤2 (OR = 2.50 (1.20-5.26) P = 0.0137), and the Bishop score ≤3 (OR = 2.62 (1.45-4.72), P = 0.0014) were significantly and independently associated to prostaglandin ripening failure. Obesity seems to be associated to lower E2 prostaglandin sensitivity.
Tristan Gauthier, Sophie Mazeau, François Dalmay, Jean-Luc Eyraud, Cyril Catalan, Benoit Marin, Yves Aubard. Obesity and cervical ripening failure risk. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians. 2012 Mar;25(3):304-7
PMID: 21574901
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