Chromosomal position effects are linked to sir2-mediated variation in transcriptional burst size.

Cory Batenchuk, Simon St-Pierre, Lioudmila Tepliakova, Samyuktha Adiga, Anna Szuto, Nazir Kabbani, John C Bell, Kristin Baetz, Mads Kærn

Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada.

Biophysical journal 2011 May 18

filter terms:

Gene expression noise varies with genomic position and is a driving force in the evolution of chromosome organization. Nevertheless, position effects remain poorly characterized. Here, we present a systematic analysis of chromosomal position effects by characterizing single-cell gene expression from euchromatic positions spanning the length of a eukaryotic chromosome. We demonstrate that position affects gene expression by modulating the size of transcriptional bursts, rather than their frequency, and that the histone deacetylase Sir2 plays a role in this process across the chromosome. Copyright © 2011 Biophysical Society. Published by Elsevier Inc. All rights reserved.

Citation

Cory Batenchuk, Simon St-Pierre, Lioudmila Tepliakova, Samyuktha Adiga, Anna Szuto, Nazir Kabbani, John C Bell, Kristin Baetz, Mads Kærn. Chromosomal position effects are linked to sir2-mediated variation in transcriptional burst size. Biophysical journal. 2011 May 18;100(10):L56-8