Analysis of somatic hypermutations of immunoglobulin gene rearrangements in childhood acute lymphoblastic leukemia.

M Braoudaki, K Katsibardi, V Giudicelli, K Karamolegou, Ch Papathanassiou, M-P Lefranc, F Tzortzatou-Stathopoulou

University Research Institute for the Study and Treatment of Childhood Genetic and Malignant Diseases, Hematology/Oncology Unit, First Department of Pediatrics, Aghia Sophia Children's Hospital, University of Athens, Athens, Greece. mbraouda@yahoo.co.uk

Cancer investigation 2011 Jun

filter terms:

The current study investigated the presence, frequency, and status of somatic hypermutations as well as their role in children with B lineage ALL. The obtained sequences were analyzed using IMGT/V-QUEST. Totally, 150 IGH sequences were evaluated; 139 from the 111 patients at the time of diagnosis and 11 from 8/111 patients at the time of relapse. The findings of the current report revealed the presence of somatically mutated V genes in childhood B lineage ALL. A higher frequency of somatic hypermutations was noted in unproductive rearrangements and was generally attributed to nucleotide mutation type, region, and IGHV gene subgroup biases.

Citation

M Braoudaki, K Katsibardi, V Giudicelli, K Karamolegou, Ch Papathanassiou, M-P Lefranc, F Tzortzatou-Stathopoulou. Analysis of somatic hypermutations of immunoglobulin gene rearrangements in childhood acute lymphoblastic leukemia. Cancer investigation. 2011 Jun;29(5):360-4