Effects of synthetic retinoid Am80 on iodide-induced autoimmune thyroiditis in nonobese diabetic mice.

Kazuki Morohoshi, Katsumi Yoshida, Yoshinori Nakagawa, Saeko Hoshikawa, Hiroshi Ozaki, Yurie Takahashi, Sadayoshi Ito, Kouki Mori

Division of Nephrology, Endocrinology and Vascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan. kokimori@yahoo.co.jp

Cellular immunology 2011

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We examined whether a synthetic retinoid Am80 prevented the development of autoimmune thyroiditis in iodide-treated nonobese diabetic mice, an animal model of Hashimoto's thyroiditis (HT). Am80 (0, 0.1 or 1 mg/kg/day) was orally administered in feed during the 8-week iodide treatment. While iodide ingestion effectively induced thyroiditis, Am80 administration failed to interfere with thyroiditis development and serum anti-thyroglobulin antibody levels regardless of the dose of the retinoid. Splenic T cell numbers, splenocyte proliferation and interferon-γ production were decreased in the Am80-treated mice. Our data suggest that Am80 is not a candidate for use in the prevention of HT. Copyright © 2011 Elsevier Inc. All rights reserved.

Citation

Kazuki Morohoshi, Katsumi Yoshida, Yoshinori Nakagawa, Saeko Hoshikawa, Hiroshi Ozaki, Yurie Takahashi, Sadayoshi Ito, Kouki Mori. Effects of synthetic retinoid Am80 on iodide-induced autoimmune thyroiditis in nonobese diabetic mice. Cellular immunology. 2011;270(1):1-4