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To detect the expression of stem cell transcription factor Oct-4 in squamous cell carcinoma (SCC) and seborrheic keratosis (SK) and its association with cancer stem cells. Immunohistochemistry was used to detect Oct-4 expression in 35 SCC cases, 21 SK cases and 15 normal control skin tissues. Oct-4 expression was negative in normal skin and showed a significant difference between SCC and SK tissues (P<0.05). The Oct-4-positive cells in SCC and SK are probably tumor stem cells. Oct-4 expression may provide an important evidence for isolation and identification of human SCC and SK stem cells.


Yu-yang Li, Yong-jiang Dai, Bin Deng, Xiong-an Liang, Zhi-jie Xie, Hai-fu Chen. Expression of Oct-4 transcription factor in squamous cell skin carcinoma and seborrheic keratosis]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2011 May;31(5):917-8

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PMID: 21602158

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