Jicai Bi, Honghai Wang, Jianping Xie
Institute of Modern Biopharmaceuticals, School of Life Sciences,Southwest University, Chongqing 400715, China. bijicai1983@126.com
Wei sheng wu xue bao = Acta microbiologica Sinica 2011 MarNicotinamide-adenine dinucleotide (phosphate) (NAD(P)) metabolism involves many fundamental cellular events, such as energy metabolism, maintenance of redox homeostasis and regulation of cell longevity. Inhibitors of essential enzymes of NAD(P) biosynthetic pathways might be promising leads for novel antibiotics, such as the NAD synthase inhibitors. This review described the crystal structural, functional properties, regulator and structure-based inhibitors design for NAD synthase. This might provide the basis for developing NAD-based therapeutics.
Jicai Bi, Honghai Wang, Jianping Xie. Microbial NAD synthetase and its inhibitors--a review]. Wei sheng wu xue bao = Acta microbiologica Sinica. 2011 Mar;51(3):305-12
PMID: 21604544
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