Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma.

Human mutation 2011 Jun

filter terms:

We performed a mutational analysis of the 19 disintegrin-metalloproteinases (ADAMs) genes in human cutaneous metastatic melanoma and identified eight to be somatically mutated in 79 samples, affecting 34% of the melanoma tumors analyzed. Functional analysis of the two frequently mutated ADAM genes, ADAM29 and ADAM7 demonstrated that the mutations affect adhesion of melanoma cells to specific extracellular matrix proteins and in some cases increase their migration ability. This suggests that mutated ADAM genes could play a role in melanoma progression. © 2011 Wiley-Liss, Inc.

Citation

Xiaomu Wei, Angela Moncada-Pazos, Santiago Cal, Clara Soria-Valles, Jared Gartner, Udo Rudloff, Jimmy C Lin, NISC Comparative Sequencing Program, Steven A Rosenberg, Carlos López-Otín, Yardena Samuels. Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma. Human mutation. 2011 Jun;32(6):E2148-75