Oncolytic viruses for the treatment of neuroendocrine tumors.

M Essand, J Leja, V Giandomenico, K E Oberg

Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Sweden. magnus.essand@igp.uu.se

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 2011 Nov

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Oncolytic viruses are emerging as anticancer agents, and they have also shown great promise for use against neuroendocrine tumors. Many viruses have a natural tropism for replication in tumor cells. Others can be genetically engineered to selectively kill tumor cells. Viruses have some advantages as therapeutic agents over current cytotoxic drugs and small molecules. They replicate in tumor cells and thereby increase in number over time leading to increased dosage. They are immunogenic and can alter the immunosuppressive tumor microenvironment and activate immune effector cells. They have also been shown to be able to kill drug-resistant cancer stem cells. This article reviews the recent literature on oncolytic viruses used so far for neuroendocrine tumors and indicates important issues to focus on in the future. Georg Thieme Verlag KG Stuttgart · New York.

Citation

M Essand, J Leja, V Giandomenico, K E Oberg. Oncolytic viruses for the treatment of neuroendocrine tumors. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme. 2011 Nov;43(12):877-83