Function of K⁺-Cl⁻ cotransporters in the acid secretory mechanism of gastric parietal cells.

Takuto Fujii, Kyosuke Fujita, Noriaki Takeguchi, Hideki Sakai

Department of Pharmaceutical Physiology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan. fujiitk@pha.u-toyama.ac.jp

Biological & pharmaceutical bulletin 2011

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Gastric proton pump (H⁺, K⁺-ATPase) secretes H⁺ of acid (HCl) via the luminal membrane of parietal cells. For the HCl secretion, Cl⁻- and K⁺-transporting proteins are required. Recent our studies have demonstrated that K⁺-Cl⁻ cotransporters (KCC3a and KCC4) are expressed in gastric parietal cells. KCC3a is associated with Na⁺, K⁺-ATPase in the basolateral membrane, and KCC4 is associated with H⁺, K⁺-ATPase in the apical canalicular membrane. This paper summarizes the functional association between KCCs and P-type ATPases and the contribution of these complexes to acid secretion in gastric parietal cells.

Citation

Takuto Fujii, Kyosuke Fujita, Noriaki Takeguchi, Hideki Sakai. Function of K⁺-Cl⁻ cotransporters in the acid secretory mechanism of gastric parietal cells. Biological & pharmaceutical bulletin. 2011;34(6):810-2