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To investigate the potential significance of platelet-derived growth factor receptor-α (PDGFR-α) and platelet-derived growth factor A (PDGF-A) expression in mammary carcinomas, and analyze its correlation with the lymph node metastasis and the expression of PDGF-A. Used immunohistochemistry to detect the protein expression of PDGFR-α and PDGF-A in paraffinembedded breast carcinomas. The expression of PDGFR-α and PDGF-A were observed in 51.7% and 61.7% in the breast carcinomas, respectively and showed an association with lymph node metastasis (P < 0. 05). A correlation was also found with the expression of PDGFR-α and PDGF-A (P<0.05). PDGFR-α is expressed in invasive breast carcinomas and is associated with biological aggressiveness.


De-shui Liu, Xiao-jie Zhang, Gang Chen, Chang-fang Lu, Hai-ying Dong. Expression of platelet-derived growth factor receptor α and its ligand PDGF- A in breast cancer]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. 2011 Mar;27(3):313-4, 316

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PMID: 21638928

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