Yu-Cheng Chang, Pei-Wen Chao, Ching-Hsuan Tung
Department of Radiology, The Methodist Hospital Research Institute, Weill Cornell Medical College, 6565 Fannin Street, #B5-009, Houston, TX 77030, United States.
Bioorganic & medicinal chemistry letters 2011 Jul 1Highly selective luminescent probes, QLUC-TYR and LUC-GLU, for detection of carboxypeptidase activity were synthesized. Caged substrates were first cleaved by corresponding carboxypeptidases, and then they were activated by luciferase to emit light. Enzymatic activities of biologically important carboxypeptidases can be determined using this technology. Copyright © 2011 Elsevier Ltd. All rights reserved.
Yu-Cheng Chang, Pei-Wen Chao, Ching-Hsuan Tung. Sensitive luciferin derived probes for selective carboxypeptidase activity. Bioorganic & medicinal chemistry letters. 2011 Jul 1;21(13):3931-4
PMID: 21640584
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