Dissociations within short-term memory in GluA1 AMPA receptor subunit knockout mice.

Amy M Taylor, Burkhard Niewoehner, Peter H Seeburg, Rolf Sprengel, J Nicholas P Rawlins, David M Bannerman, David J Sanderson

Department of Experimental Psychology, University of Oxford, South Parks Road, Oxford OX1 3UD, UK.

Behavioural brain research 2011 Oct 10

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GluA1 AMPA receptor subunit knockout mice display a selective impairment on short-term recognition memory tasks. In this study we tested whether GluA1 is important for short-term memory that is necessary for bridging the discontiguity between cues in trace conditioning. GluA1 knockout mice were not impaired at using short-term memory traces of T-maze floor inserts, made of different materials, to bridge the temporal gap between conditioned stimuli and reinforcement during appetitive discrimination tasks. Thus, different aspects of short-term memory are differentially sensitive to GluA1 deletion. This dissociation may reflect processing of qualitatively different short-term memory traces. Memory that results in performance of short-term recognition (e.g. for objects or places) may be different from the memory required for associative learning in trace conditioning. Copyright © 2011 Elsevier B.V. All rights reserved.

Citation

Amy M Taylor, Burkhard Niewoehner, Peter H Seeburg, Rolf Sprengel, J Nicholas P Rawlins, David M Bannerman, David J Sanderson. Dissociations within short-term memory in GluA1 AMPA receptor subunit knockout mice. Behavioural brain research. 2011 Oct 10;224(1):8-14